CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

CONTENTS

1. The CRISPR/Cas9 Genome-editing System: Principles and Applications

Cecilia Pop-Bica, Andreea Nutu, Roxana Cojocneanu, Sergiu Chira and Ioana Berindan-Neagoe

2. Recent Applications of CRISPR-Cas9 in Genome Mapping and Sequencing

Dharma Varapula, Lahari Uppuluri and Ming Xiao

3. Gene Editing and Genetic Disorders: Ethical and Legal Concerns

Vicente Bellver and Federico de Montalvo

4. Political, Regulatory and Ethical Considerations of the CRISPR/Cas Genome Editing Technology

Eduardo Rodriguez Yunta and Luis María Vaschetto

5. CRISPR/Cas and Gene Therapy: An Overview

Luis María Vaschetto

6. CRISPR and Cancer: From Bench to Clinic

Muhammad Usama Tariq and Amina Chaudhry

7. The Advances of the CRISPR/Cas9 Technology for Correcting Genetic Disorders: Using Sarcoma as a Model System

Pichaya Thanindratarn, Dylan C. Dean, Francis J. Hornicek and Zhenfeng Duan

8. CRISPR/Cas9 Technology as a Strategy Against Viral Infections

Huafeng Lin, Haizhen Wang, Jun He, Xiangwen Peng, Aimin Deng, Lei Shi, Lei Ye and Hanyue Gong

9. CRISPR/Cas9-based Genome and Epigenome Editing in Neuroscience Research

Nereo Kalebic and Wieland B. Huttner

10. Non-viral Alternatives to Delivery of CRISPR-Cas Gene Editing Components

Kate Senger and Benjamin Haley

11. CRISPR Medicine: Advance, Progress and Challenges

Guillermo Ureña-Bailén, Justin S. Antony, Yujuan Hou, Janani Raju, Andres Lamsfus-Calle, Alberto Daniel-Moreno, Rupert Handgretinger and Markus Mezger