Diagnostic Pathology: Breast, 4th Edition

• Incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today’s practice
• Emphasizes the correlation of pathologic lesions with findings on breast imaging and provides guidance on the interpretation of core needle biopsies
• Contains new overview chapters that lay the groundwork for initial evaluation and assistance with differential diagnosis, as well as new chapters on HER2-low breast carcinoma, immunohistochemical studies for diagnosis, proliferation, and more
• Provides important updates throughout, covering the evaluation of ESR1, PIK3CA, AKT, and BRCA1 mutations to guide therapy; tumor-infiltrating lymphocytes and PD-L1 for treatment planning; HER2-low assessment to determine eligibility for antibody-drug conjugates; and much more
• Features new animations and new videos to assist in understanding three-dimensional anatomy, radiologic-pathologic correlation, the processing of breast specimens, and the gross identification of breast lesions
• Contains more than 3,700 extensively annotated images, including gross pathology photographs, histopathology photomicrographs, a wide range of immunohistochemical stains, fluorescent in situ hybridization, breast-imaging studies, and full-color illustrations
• Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care
• Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

CONTENTS

SECTION 1: NORMAL BREAST

Histology of Normal Breast
Breast Life Cycle Changes

SECTION 2: BREAST SPECIMENS

Breast Specimens Overview
Core Needle Biopsies
Excisions and Oncoplastic Surgery
Margins and Reexcisions
Mastectomies
Reduction Mammoplasties
Lymph Nodes
Intraoperative Consultation

SECTION 3: OVERVIEW

Papillary Lesions
Spindle Cell Lesions
Small Acinar Proliferations
Epithelial/Myoepithelial Lesions
Vascular and Pseudovascular Lesions
Lesions with Inflammatory Cells
Nipple Lesions
Iatrogenic Changes
Immunohistochemical Studies

SECTION 4: BENIGN CHANGES

Nonproliferative Changes
Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia
Usual Ductal Hyperplasia
Sclerosing Adenosis
Radial Sclerosing Lesion/Radial Scar
Papilloma, Large Duct and Small Duct
Nipple Adenoma
Mucocele-Like Lesions
Collagenous Spherulosis
Juvenile Papillomatosis
Gynecomastia in Men and Gynecomastia-Like Changes in Women
Hamartoma (Fibroadenolipoma)
Syringomatous Tumor of the Nipple
Adenomyoepithelioma
Cystic Hypersecretory Lesions
Microglandular Adenosis
Atypical Ductal Hyperplasia
Atypical Lobular Hyperplasia

SECTION 5: CARCINOMAS

Risk Factors for Developing Carcinoma

Risk Factors for Developing Breast Carcinoma
Epidemiology: Lesions Conferring Increased Risk of Breast Carcinoma

Carcinoma In Situ

Lobular Carcinoma In Situ
Ductal Carcinoma In Situ
Ductal Carcinoma In Situ, Paget Disease

Special Papillary Carcinomas

Encapsulated Papillary Carcinoma
Solid Papillary Carcinoma

INVASIVE CARCINOMA

Invasive Carcinoma: Histologic and Molecular Classifications
Male Breast Carcinoma

Histologic Types

Invasive Breast Carcinoma of No Special Type
Microinvasive Carcinoma
Invasive Lobular Carcinoma
Invasive Tubular Carcinoma and Invasive Cribriform Carcinoma
Invasive Mucinous (Colloid) Carcinoma
Invasive Papillary Carcinoma
Invasive Micropapillary Carcinoma
Invasive Apocrine Carcinoma
Invasive Neuroendocrine Carcinoma
Invasive Carcinoma with Osteoclast-Like Giant Cells
Metaplastic Carcinoma
Adenoid Cystic Carcinoma
Secretory Carcinoma

Biologic Types

Luminal Carcinoma (ER Positive/HER2 Negative)
HER2-Positive Carcinoma
HER2-Low Breast Carcinoma
Triple Negative Breast Carcinomas and Basal-Like Carcinomas

SECTION 6: PROGNOSTIC AND PREDICTIVE FACTORS

Overview of Prognostic and Predictive Factors
AJCC Breast Cancer Staging

Anatomic Factors

Histologic Grade
Size and Multiple Foci
Lymphovascular Invasion
Inflammatory Carcinoma
Locally Advanced Carcinoma
Lymph Node Metastases
Response to Neoadjuvant Therapy
Locally Recurrent Carcinoma
Carcinoma with Extensive Intraductal Component

Molecular Factors

Hormone Receptors (ER/PR/AR)
HER2
Proliferation
DNA Analysis and Gene Copy Number Alterations
Circulating Tumor Cells, Circulating Tumor DNA, and Next-Generation Sequencing Immunotherapy
Expression Profiling, mRNA: Overview
Expression Profiling: Oncotype DX Assay
Expression Profiling: MammaPrint Assay
Expression Profiling: Prosigna
Expression Profiling: EndoPredict
Expression Profiling: Protein

SECTION 7: STROMAL LESIONS

Pseudoangiomatous Stromal Hyperplasia
Nodular Fasciitis
Fibromatosis
Myofibroblastoma
Lipoma and Angiolipoma
Fibroadenoma
Phyllodes Tumor
Granular Cell Tumor
Papillary Endothelial Hyperplasia
Hemangiomas
Atypical Vascular Lesions: Post Radiation
Angiosarcoma
Sarcomas

SECTION 8: INFLAMMATORY LESIONS

Lactational Abscess
Nonlactational Abscess
Squamous Metaplasia of Lactiferous Ducts
Fat Necrosis
Duct Ectasia
Sarcoidosis
Amyloid of the Breast
Lupus Mastitis
IgG4-Related Sclerosing Mastitis
Lymphocytic Lobulitis/Mastopathy
Implant Pathology

Section 9: Other Types of Malignancies

Hematopathologic Malignancies
Metastases to Breast

SECTION 10: HEREDITARY BREAST DISEASE

Overview of Hereditary Breast Cancer
Table of Germline Mutations
BRCA1
BRCA2
Li-Fraumeni Syndrome