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Protein Homeostasis Diseases, Mechanisms and Novel Therapies

Protein Homeostasis Diseases, Mechanisms and Novel Therapies
Protein Homeostasis Diseases, Mechanisms and Novel Therapies
  • Author: Angel L. Pey
  • ISBN: 9780128191323
  • Publisher: Elsevier
  • Pages: 450
  • Dimensions: 191 X 235 mm
  • Year Published: 2020
Ex Tax: 175.47€

  • Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands
  • Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease
  • Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance
Table Of Contents:

I. Introduction of protein folding and homeostasis
1. Protein folding: how, why, and beyond
2. Protein homeostasis and disease

II. Protein folding and homeostasis at the organismal and proteomic scales
3. Caenorhabditis elegans as a model organism for protein homeostasis diseases
4. Proteome-scale studies of protein stability
5. Classifying disease-associated variants using measures of protein activity and stability

III. Protein homeostasis disturbance in disease: Genetics, mechanisms, and modulation by natural ligands
6. Protein destabilization and degradation as a mechanism for hereditary disease
7. Detection of amyloid aggregation in living systems
8. Molecular mechanisms of amyloid aggregation in human proteinopathies
9. Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
10. Vitamin B6-dependent enzymes and disease
11. Galactosemia: opportunities for novel therapies
12. Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors
13. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases
14. Virtual screening in drug discovery: a precious tool for a still-demanding
15. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
16. Cellular high-throughput screening
17. High-throughput screening for intrinsically disordered proteins by using biophysical methods
18. Natural and pharmacological chaperones against accelerated protein degradation: uroporphyrinogen III synthase and congenital erythropoietic porphyria

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