insufficiency/deficiency is a worldwide, public health problem in both
developed and developing countries. Rickets among infants has reemerged.
Low levels of vitamin D are associated with increased risk and
mortality from cancer. At the same time, the beneficial effects of
vitamin D on a host of conditions have recently been discovered.
Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging.
A state-of-the-art compilation of essential information, this book explores:
Vitamin D and its genomic and nongenomic effects, the role of
therapeutic analogs in treating disease, and the production of vitamin D
by the body
The role vitamin D plays in modulating oxidative stress—with
emphasis on cancer, stress-mediated diseases, photo-protection of the
skin, and energy metabolism
Beneficial effects of vitamin D in regulating the immune response
and its importance in protecting against autoimmune, infectious, and
The role vitamin D plays in the regulation of the aging
process—including aspects of oxidative stress, senescence, and
mortality, as well as its role in protection against cardiovascular
disease and nervous system disorders
This book represents an important contribution toward understanding
the mechanisms by which vitamin D promotes health, increasing awareness
of the importance that vitamin D plays during development, at birth, and
throughout the aging process. It is a valuable reference for
researchers in academia, nutrition, medicine, and industry.
Table of Contents
Vitamin D: An Overview Vitamin D: A Fountain of Youth in Gene Regulation; Peter W. Jurutka, G. Kerr Whitfield, Ryan Forster, Shane Batie, Jamie Lee, and Mark R. Haussler Vitamin D Receptor: Genomic and Epigenomic Effects; Prashant K. Singh and Moray J. Campbell Vitamin D Analogs and Their Clinical Uses; Glenville Jones Extrarenal CYP27B1 and Vitamin D Physiology; Martin Hewison Oxidative Stress Vitamin D and Oxidative Stress; Huei-Ju Ting and Yi-Fen Lee Vitamin D3 Upregulated Protein 1 (VDUP1): Roles in Redox Signaling and Stress-Mediated Diseases; Dong Oh Kim, Hyun Woo Suh, Haiyoung Jung, Young Jun Park, and Inpyo Choi Vitamin D and Its Role in Photoprotection of the Skin; Clare Gordon-Thomson, Wannit Tongkao-on, and Rebecca S. Mason Vitamin
D and Adipose Tissue: 1α, 25-Dihydroxyvitamin D3 (Calcitriol)
Modulation of Energy Metabolism, Reactive Oxygen Species, and
Inflammatory Stress; Antje Bruckbauer and Michael B. Zemel Membrane Receptors for Vitamin D Metabolites and the Role of Reactive Oxygen Species; Ramesh C. Khanal and Ilka Nemere Immunity and Disease Vitamin D and Human Innate Immunity; Eun-Kyeong Jo, Dong-Min Shin, and Robert L. Modlin Vitamin D and Autoimmune Disease; Colleen E. Hayes, Corwin D. Nelson, and Justin A. Spanier Vitamin D: Anti-Inflammatory Actions to Prevent and Treat Diseases; Jun Sun Vitamin D and Infection; Jim Bartley and Carlos A. Camargo, Jr. Aging Potential Role of Vitamin D and Fibroblast Growth Factor 23–Klotho System in Aging; Nasimul Ahsan, Syed K. Rafi, Beate Lanske, and Mohammed S. Razzaque Vitamin D and Cardiovascular Disease; Jared P. Reis and Pamela L. Lutsey Vitamin D, Aging, and Chronic Diseases; Pentti Tuohimaa Vitamin D: Defending the Aging Nervous System; Cédric Annweiler Index