Stress and Epigenetics in Suicide

• Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational
• Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment
• Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors
• Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

Chapter 1: Recent Tendencies in Suicide and Mental Health Among Younger Generations and Current Explanations

• Abstract
• Youth suicides-is it really growing worldwide?
• Suicide among young people in the European continent
• Children and adolescent suicides in the countries of the former USSR
• Youth suicides in Asia and the far East
• Situation in North America, Australia, and New Zealand
• Suicide among young people in Latin America and Africa
• Youth is under threat-preliminary conclusions
• Youth mental health problems-are they growing too?
• Subjective complaints in adolescents and values shift as signs of stress

Chapter 2: Neurobiology of Stress-From Homeostasis to Allostasis and How Social Environment is Involved

• Abstract
• Psychosocial stress and modernization
• Neuroendocrinology of stress response-how psychosocial stress affects health
• From homeostasis to allostasis and how social environment is involved
• Stress and the brain-mental health consequences
• Stress across the life-span and social factors

Chapter 3: What Is Epigenetics? Is It Transgenerational?

• Abstract
• Epigenetics-new life of old ideas and modern definitions
• Molecular mechanisms of epigenetics and epigenetic inheritance-a short review
• Epigenetics and ontogenetic programming
• Epigenetic events in preembryonic and early embryonic development
• Nutrition, body growth, and epigenetics of older age diseases
• Epigenetics of ecological hazards, in aging and cancer
• Epigenetic paradigm and evolutionary biology

Chapter 4: Biological Embedding-How Early Life Stress Shapes Behaviors Later in Life and How Vulnerability is Built

• Abstract
• Early life stress and behavioral epigenetics-animal models
• Early life stress and epigenetic programming of behavior and mental health in humans
• Life-time stress experiences and epigenetics
• Biological embedding-how social environment “gets under the skin”

Chapter 5: Interactions and Integrations-Biobehavioral Model of Suicide Based on Genetics, Epigenetics, and Behavioral Adjustment

• Abstract
• Theories and models of suicidal behavior-how they encounter stress
• Heritability of suicide-classical behavioral genetics studies
• Suicide genetics-genes-to-environment interactions and vulnerable phenotypes
• Epigenetic findings in suicide
• Biobehavioral-psychological-existential model of suicide

Chapter 6: Ideas for Prevention

• Abstract
• Conceptual framework and prevention strategies limitations
• How resilience is built? The earlier-the better
• Adolescents’ resilience-the power of body and mind
• Adolescents’ resilience-the power of meaning